Bolton's squad was given a clean bill of health after Saturday's goalless draw with Fulham.
Long-term injury victims Joey O'Brien and the out-of-contract Gavin McCann remain their only absentees.
West Ham
Doubtful: Hitzlsperger (thigh), McCarthy (fitness)
Injured: Collison, Hines & Kurucz (all knee)
Bolton
Injured: McCann (ankle), J O'Brien (knee)
MATCH PREVIEW
New owners, a new manager and a new season, but it was the same old West Ham on display at Aston Villa last weekend.
West Ham have got a fantastic squad of players, and a big squad of players, so they could chop and change and bring more quality in... We have to be ready to do our best and play at the top of our game
Bolton boss Owen Coyle
The Hammers registered just a single shot on target against Villa as they slumped to a 3-0 defeat. It was a dreadful start to the new job for Avram Grant, whose side were thoroughly outplayed in a disjointed and nervy display.
Next up is Bolton, who are chasing a sixth successive victory over the Hammers. Wanderers began their season with a goalless draw against another London club, Fulham. Although manager Owen Coyle will have been disappointed with his side's lack of cutting edge, he will have been delighted with a first clean sheet of the season, something that took 21 games to achieve last term.
West Ham's last seven Premier League victories all came at Upton Park. Given that their next two league games are against Manchester United and Chelsea, they will be desperate to get their season up and running here.
MATCH FACTS
Head-to-head
• West Ham haven't beaten Bolton since the 2006-07 season.
• Upton Park gave Owen Coyle his first away win as Bolton manager, a 2-1 triumph in March.
• Bolton captain Kevin Davies has hit the target in four of his last five starts against West Ham.
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West Ham
• West Ham's last seven victories all came at Upton Park.
• If fit, Thomas Hitzlsperger's West Ham debut will be his 100th Premier League appearance. His previous 99 matches came for Aston Villa between 2000 to 2005.
Bolton
• Bolton's goalless draw against Fulham was their first clean sheet in nine games.
• Wanderers will be looking to extend their unbeaten start to the season to two games for the first time since 2006.
LEADING GOALSCORERS
West Ham
Yet to score
Bolton
Yet to score
MATCH OFFICIALS
Referee: Andre Marriner
Assistant referees: Ron Ganfield & Scott Ledger
Fourth official: Gavin Ward
LAST LEAGUE MATCH LINE-UPS
West Ham (L0-3 v Aston Villa, a): Green, Reid, Tomkins (Diamanti 72), Upson, Ilunga, Faubert, Parker, Kovac (Piquionne 46), Noble, Boa Morte (Barrera 46), Cole. Subs Not Used: Stech, Gabbidon, Spector, Sears.
Bolton (D0-0 v Fulham, h): Jaaskelainen, Steinsson, Cahill, Knight, Robinson, Lee, Muamba (Mark Davies 86), Holden, Petrov (Taylor 86), Kevin Davies, Elmander (Klasnic 90). Subs Not Used: Bogdan, Ricketts, Blake, Andrew O'Brien.
Source: BBC Sport
Source: BBC Sport