Manchester United boss Sir Alex Ferguson will recall the bulk of the side that beat Liverpool after making 11 changes at Scunthorpe.
Rio Ferdinand is expected to make his first Premier League appearance of the season, while Ferguson has revealed Owen Hargreaves is back in training.
Bolton
Suspended: Cahill (one match)
Doubtful: Gardner (thigh), A O'Brien (hamstring), J O'Brien (fitness), Samuel (calf)
Injured: Davis (knee)
Manchester United
Injured/unavailable: Carrick (Achilles), Hargreaves (fitness), Valencia (ankle)
MATCH PREVIEW
Another week, another north-west derby for Manchester United, who make the short journey to Bolton's Reebok Stadium looking for a sixth consecutive victory over their Lancashire neighbours.
It's been a few years since we got a win against them. It would be nice to come away with a big result
Bolton captain Kevin Davies
Following epic encounters with Everton and Liverpool, Sir Alex Ferguson will be hoping for something more routine at a ground where his side have suffered just one defeat in 11 visits. Defensive lapses have already cost United four points this season, and Rio Ferdinand's return to fitness is a major boost.
Man-of-the-moment Dimitar Berbatov will return to United's attack having sat out the midweek Carling Cup win over Scunthorpe. The Bulgarian has responded to criticism of his perceived lack of work-rate with a series of dazzling displays, and confirmed his renaissance with his first hat-trick for the club against Liverpool on Sunday.
Bolton have already suffered one derby defeat this week, losing 1-0 to Burnley in the Carling Cup, but Owen Coyle will be satisfied with his side's start to the season. Wanderers have lost just once in the league so far, but need to start turning draws into wins as they look to improve on last season's 14th-place finish.
MATCH FACTS
Head-to-head
• Man Utd have won 10 of their last 11 meetings against Bolton, and lost only one of their 11 Premier League games at Wanderers.
• Wayne Rooney has scored six goals in his last four league matches against Bolton, although his last visit to the Reebok was back in October 2006.
Have your say on this match
Bolton
• Bolton have drawn three of their last four matches at the Reebok Stadium.
• Kevin Davies has been booked eight times against Manchester United in the Premier League. He has only been cautioned more often against Arsenal (10 bookings).
Manchester United
• Wayne Rooney hasn't scored a Premier League goal at an away ground since January (a 3-1 win at Arsenal).
• Dimitar Berbatov has had more shots on target (12) than any other Premier League player this season.
• United have scored four goals from corners, more than anyone else in the Premier League.
LEADING GOALSCORERS
Bolton
Elmander: 3 goals (3 league); K Davies: 2 goals (2 league)
Manchester United
Berbatov: 7 goals (6 league); Fletcher: 2 goals (2 league), Owen: 2 goals (0 league)
MATCH OFFICIALS
Referee: Phil Dowd
Assistant referees: Bob Pollock & Glenn Turner
Fourth official: Mark Clattenburg
LAST LEAGUE MATCH LINE-UPS
Bolton (D1-1 v Aston Villa, a): Bogdan, Steinsson, Knight, Andrew O'Brien (Ricketts 18), Robinson, Petrov (Taylor 83), Muamba (Mark Davies 69), Holden, Lee, Kevin Davies, Elmander. Subs Not Used: Lainton, Klasnic, Moreno, Blake.
Manchester United (W3-2 v Liverpool, h): Van der Sar, O'Shea, Vidic, Jonathan Evans, Evra, Nani (Gibson 88), Fletcher, Scholes, Giggs (Macheda 82), Berbatov (Anderson 88), Rooney. Subs Not Used: Kuszczak, Brown, Owen, Smalling.
Source: BBC Sport
Source: BBC Sport